Total platinum composed of proteins related and unrelated proteins platinum, whereas platinum amenable ultrafiltration consists of carboplatin and unbound proteins metabolites of carboplatin. In pharmacokinetic studies of carboplatin is usually measured by the platinum level, drostanolone enanthate amenable to ultrafiltration as cytotoxic usually only unbound proteins platinum or its metabolites containing platinum.
After a single injection of carboplatin as an intravenous infusion the maximum concentrations of carboplatin, total platinum and platinum amenable ultrafiltration achieved almost immediately. Platinum is distributed in all body tissues and fluids, with the highest concentrations observed in kidneys, liver, skin, and tumor tissues.
The initial , carboplatin, platinum and total platinum amenable to ultrafiltration, by intravenous administration are almost identical.
Actually carboplatin does not bind to proteins, and degraded to products containing platinum, which is very quickly binds with proteins. During the first drostanolone enanthate 4 hours after administration of carboplatin platinum less than 24% bound to plasma proteins; after 24 hours the number of related platinum is 87%.
The concentration of carboplatin and platinum amenable ultrafiltration, reduced in accordance with the two-phase model. The total concentration of platinum is reduced in accordance with the three-phase model. In normal renal function, half-lives of carboplatin and platinum amenable ultrafiltration is 2-3 hours, total terminal half-life of 4-6 days platinum.
Carboplatin and platinum-metabolites are mainly excreted in the urine. In normal renal function about 65% carboplatin dose excreted in the urine during 12 hours; after 24 hours 71% of the dose output. Much of excreted as unchanged carboplatin. Carboplatin (in the form of carboplatin, verifiable ultrafiltration) is effectively displayed by hemodialysis.
In the urine after 24 hours, all the platinum is present as carboplatin. Only 3-5% of the administered platinum is excreted in the urine during the period of 24-96 hours.
As carboplatin is derived almost entirely by glomerular filtration, only a very small concentration of carboplatin is present in the renal tubules, which may explain the small nephrotoxic potential of the drug as compared with cisplatin .
- ovarian cancer
- germ cell tumors of men and women,
- lung cancer,
- cervical cancer drostanolone enanthate,
- Malignant tumors of the head and neck,
- transitional cell bladder cancer
- Hypersensitivity to carboplatin or other platinum-compounds;
- pronounced renal dysfunction (creatinine clearance less than or equal to 15 mL / min);
- severe myelosuppression;
- heavy bleeding;
- Pregnancy and lactation
- Children’s age drostanolone enanthate (safety and efficacy of poorly understood)