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drostanolone

By blocking cholinergic synapses located in the sphincter of the pupil and the ciliary muscle, there is an expansion of the pupil due to the predominance of tone muscles, dilates the pupil and relax the muscles, which narrows the pupil . At the same time due to relaxation of the ciliary (accommodative) muscles occurs paralysis of accommodation (cycloplegia). Pupil dilation occurs within 15-30 drostanolone minutes after a single instillation. Mydriasis is maintained for 6-12 hours, in particularly sensitive patients, easy mydriasis may persist much longer. Residual effects tsikpoplegii persist for 12-24 hours. The drug has mild antispasmodic effect, reduces the secretion of salivary, gastric, bronchial, sweat glands and the pancreas; increases intraocular pressure; It reduces vagal tone, which leads to an increase in heart rate with a slight increase in blood pressure.
It penetrates the blood-brain barrier; in medium therapeutic doses has a mild stimulating effect on the central nervous system, has a stimulating effect on the respiratory center. Well absorbed through the conjunctiva. Significant levels is achieved at 0.5 – 1 hour. Plasma protein binding is moderate.

testimony

  • For diagnostic purposes: the ophthalmoscopy; determining refraction.
  • The preoperative preparation: to expand the pupil during cataract.
  • In inflammatory diseases of the front eye section – episcleritis, sclerites, keratitis, iridocyclitis, uveitis – in the complex therapy.

 

Contraindications

  • Suspected glaucoma; glaucoma drostanolone;
  • Post-traumatic paresis of musculus sphincter pupillae iris;
  • Hypersensitivity to the drug.

 

Precautions
Children age – up to 3 years; elderly age; bowel obstruction; prostatic hyperplasia.

Pregnancy and lactation
Since the effect of the drug in pregnant women and nursing mothers has been insufficiently studied, the use of this category of patients is possible if the expected benefits exceed the risk of possible side effects in the fetus and child.

Dosing and Administration
Locally. Instilled into the conjunctival sac of 1 – 2 drops.
For a survey of the fundus:. 1 – 3 times with 1 drop every 10 minutes
In the study of refractive errors in children and adolescents: 2-3 times a day for 1 – 2 drops at intervals of 15 20 minutes.
in inflammatory diseases: 3 to  drostanolone1 drop twice a day in severe cases the use of permissible 1 drop every 3-4 hours.

Side effects:
Redness of the conjunctiva and discomfort after instillation, temporary reduction in visual acuity.
Increased intraocular pressure in patients with primary glaucoma. Weakness, nausea, dizziness, and tachycardia.
In children who are sensitive to cyclopentolate may be general weakness, nausea, dizziness, drowsiness, dry mouth, headache, rarely tachycardia.