Gastric lavage, activated uglya.Lechenie symptomatic. In a joint application with blockers, phenothiazine derivatives, tricyclic antidepressants increase the expression of peripheral anticholinergic effects with chlorpromazine -. May reduce its concentration in the plasma
under the influence of reserpine antiparkinsonian action trihexyphenidyl decreases (depletion of dopamine reserves in the masterone, activation of cholinergic neurons) .
Levodopa increases the activity of anti-trihexyphenidyl. When applied with both drugs levodopa dosage should be reduced. Usually it is sufficient to 6.3 mg trihexyphenidyl per day, divided into two steps.
Influenced inhibitors may increase anticholinergic action anticholinergics used in parkinsonism. With simultaneous use of trihexyphenidyl reduced effect of sublingual nitrates used (due to dry mouth).Depressive effect of alcohol and drugs that affect the central masterone nervous system may be enhanced when used with trigeksifenidilom.
In the period of treatment should refrain from driving motor vehicles and activities potentially hazardous activities that require high concentration and psychomotor speed reactions. Treatment should not be stopped suddenly. If you are taking the drug there is dryness of the mouth, it is desirable to take before eating, as otherwise, may appear nausea.
At the end of the treatment or in case of alternative treatment trihexyphenidyl dose should be reduced gradually.
Patients older than 60 years is prescribed with extreme caution due to the increased sensitivity to the drug, the possibility of deterioration of memory and thinking. When large doses of the drug or in patients with predisposing factors (atherosclerosis, advanced age masterone or patients who previously appeared idiosyncrasy to any drug) can appear mental disorders (unnatural increase in mood, agitation, irritability), vomiting or nausea . In these cases it is necessary to stop treatment.
During the long treatment severity of side effects caused by anticholinergic effect, decreases. Intraocular pressure should be monitored regularly.